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SG has also been analyzed in 62 patients with refractory SCLC included in the IMMU-132-01 phase I-II trial, showing an ORR of 17.7%, a median PFS of 3.7 months and a median OS of 7.1 months [48,92]

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Anecdotal reports from Phase 2 participants suggest that nausea severity is higher when dosing occurs in the early morning on an empty stomach, possibly because fasting amplifies the compound's gastric-slowing effect

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This underscores that GSTM1 and GSTT1 genotypes are key determinants for stratifying individuals who would derive maximum benefit from SFN-based chemoprevention for colorectal cancer, with age and smoking history providing critical contextual refinement

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